Serum malondialdehyde levels during amlodipine and nifedipine-GITS antihypertensive treatment

Nifedipine GITS Package Insert

A review of the gastrointestinal therapeutic system (GITS) formulation and its effectiveness in the delivery of antihypertensive drug treatment (focus on nifedipine GITS)

Hypertension treatment guidelines do not discriminate within drug classes and, furthermore, do not consider whether or not all of the formulations of any given drug licensed for once-daily administration can be considered to be therapeutically interchangeable. This article focuses on this issue with respect to nifedipine and the development of the gastrointestinal therapeutic system (GITS) form...

A comparative crossover evaluation of amlodipine and nifedipine GITS before and after a missed dose: 48-h blood pressure profiles.

Despite good pharmacologic control of blood pressure (BP), the untoward effects of noncompliance and missed doses have become a matter of concern, evidenced by the high frequency of deviations from prescribed treatment. Missing one or more days of medication on these “drug holidays” can disrupt the steady level of the drug and lead to rebound reactions when the dose is suddenly stopped, and res...

Differential effects of lercanidipine and nifedipine GITS on plasma norepinephrine in chronic treatment of hypertension.

This study aimed to compare the effects of two long-acting dihydropyridine calcium channel blockers (CCBs) with different pharmacologic properties, lercanidipine and nifedipine Gastro-Intestinal Therapeutic System (GITS), in the chronic treatment of essential hypertension. After a 4-week placebo run-in period, 60 patients of both sexes were randomly treated with lercanidipine 10 to 20 mg or nif...

High-risk patients benefit most from nifedipine GITS–telmisartan combination